Description
Primate Biologicals supplies research-grade cynomolgus monkey cerebrospinal fluid (CSF) exclusively sourced from healthy, SPF-status Macaca fascicularis housed at USDA-licensed facilities in the United States. Our cynomolgus CSF is available as pooled or individual donor samples in both fresh and cryopreserved formats to support your neuroscience research, CNS drug development, and preclinical toxicology studies.
Cynomolgus macaques share remarkable neuroanatomical and physiological similarities with humans, making cynomolgus monkey CSF an essential biological matrix for translational research. The cerebrospinal fluid circulates through the brain ventricles and spinal canal, providing critical insights into central nervous system homeostasis, biomarker profiles, and blood-brain barrier function.
Research Applications
Cynomolgus monkey cerebrospinal fluid supports a broad range of preclinical and translational research applications:
- Neurodegenerative disease biomarker research — Quantification of amyloid beta (Aβ40, Aβ42), total tau (t-tau), phosphorylated tau (p-tau), and neurofilament light chain (NfL) for Alzheimer’s, Parkinson’s, and Huntington’s disease models
- Intrathecal drug delivery studies — Evaluation of CNS drug distribution, pharmacokinetics, and blood-brain barrier penetration following IT administration
- CNS pharmacology and toxicology — Assessment of therapeutic compound exposure and safety profiles in the central nervous system
- Gene therapy development — Monitoring of transgene expression and vector biodistribution in neurological gene therapy programs
- Assay development and validation — Development of immunoassays, ELISA, Western blot, and mass spectrometry methods using NHP CSF matrix
- Comparative physiology studies — Characterization of CSF biochemistry, cytology, and protein profiles across primate species
Product Specifications
| Specification | Details |
| Species | Cynomolgus monkey (Macaca fascicularis) |
| Source | Healthy, SPF-status animals from U.S. facilities |
| Sample Types | Pooled or individual donor samples |
| Sex Options | Male, female, or no preference |
| Collection Method | Cisterna magna or lumbar puncture under aseptic conditions |
| Format | Fresh or cryopreserved |
| Storage | -80°C; avoid repeated freeze-thaw cycles |
| SKU | C-CSF |
Why Choose Primate Biologicals for Cynomolgus CSF?
- 100% U.S. Origin: All cynomolgus monkey CSF is sourced exclusively from primates housed at USDA-licensed facilities in the United States, ensuring full regulatory traceability and documentation.
- SPF-Status Animals: CSF is collected from specific pathogen-free cynomolgus monkeys screened for common viral and bacterial agents.
- Flexible Sample Options: Choose between pooled samples for larger-scale studies or individual donor samples with matched donor demographics for longitudinal research.
- Quality-Controlled Collection: CSF is collected using aseptic technique to minimize blood contamination and preserve biomarker integrity.
- Comprehensive Documentation: Each lot includes collection date, donor information (age, sex, weight), and handling records.
- Custom Collection Services: Request specific volumes, donor matching, or paired sample collection (CSF with matched serum/plasma) for your research protocol.
Frequently Asked Questions
What is cynomolgus monkey CSF used for in research?
Cynomolgus monkey cerebrospinal fluid is widely used in neuroscience research to study CNS biomarkers, evaluate intrathecal drug delivery systems, assess blood-brain barrier penetration of therapeutic compounds, and develop preclinical models of neurodegenerative diseases including Alzheimer’s, Parkinson’s, and multiple sclerosis.
How is cynomolgus monkey CSF collected?
CSF is collected from anesthetized animals via cisterna magna puncture or lumbar puncture using sterile technique. Collection adheres to IACUC-approved protocols and animal welfare guidelines. The method minimizes blood contamination to preserve sample quality for sensitive biomarker assays.
What is the difference between pooled and individual CSF samples?
Pooled CSF combines samples from multiple donors, providing a normalized matrix ideal for assay development, method validation, and studies requiring larger volumes. Individual donor CSF maintains single-animal provenance with full demographic data, supporting longitudinal studies, inter-individual variability research, and regulatory submissions requiring donor traceability.
How should cynomolgus monkey CSF be stored and handled?
Store cryopreserved CSF at -80°C upon receipt. Avoid repeated freeze-thaw cycles as this can degrade protein biomarkers. For single-use aliquoting, thaw samples on ice, divide into working aliquots, and refreeze immediately. Fresh CSF should be processed within 24-48 hours of collection.
Why choose cynomolgus monkeys for CSF research over other NHP species?
Cynomolgus macaques (Macaca fascicularis) are the most widely used non-human primate in biomedical research due to their close genetic and physiological similarity to humans. Their brain architecture, CSF composition, and CNS drug metabolism closely parallel human biology, making cynomolgus CSF an excellent translational model for neuroscience and CNS drug development programs.
Can I request matched samples (CSF with serum or plasma)?
Yes. Primate Biologicals offers custom collection services including paired CSF and blood-derived samples from the same donor. Contact us to discuss your specific requirements for matched sample sets, custom volumes, or specialized collection protocols.